Download e-book for iPad: An introduction to toxicogenomics by Michael E. Burczynski

By Michael E. Burczynski

ISBN-10: 0849313341

ISBN-13: 9780849313349

Because the creation of cDNA microarrays, oligonucleotide array know-how, and gene chip research, genomics has revolutionized the whole box of biomedical examine. A byproduct of this revolution, toxicogenomics is a fast-rising famous person inside of toxicological research. accumulating jointly major authors and scientists on the leading edge of the sector, An advent to Toxicogenomics presents a complete evaluation of this new self-discipline. With a spotlight on toxicology, it introduces the fundamental rules of microarray/oligonucleotide array-based genomic research and explains the way it matches into the sphere of biomedical examine. those discussions supply an outline to the particular mechanics of the analyses themselves and provide insights on dealing with and quality controls. Then the booklet beneficial properties an immense part at the fundamentals of knowledge research and clustering tools equivalent to genetic algorithms. eventually, it covers the applying of expression profiling within the box of toxicology and addresses the 2 basic varieties of research intimately, with sections devoted to either mechanistic and predictive studies.Although toxicogenomics supplies quickly, effective concepts and information-rich information, a lot of its power is still untapped. An creation to Toxicogenomics consolidates the innovations underlying the sphere to supply a superb starting place from which to start your examine endeavors.

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67, 155, 2002. 24. , Use of cDNA microarray in the search for molecular markers involved in the onset of Alzheimer’s disease dementia, J. Neurosci. , 65, 471, 2001. 25. Ramakrishnan, R. , 30, e30, 2002. 26. Ramdas, L. , 2, research0047, 2001. 27. Schulze, A. , Navigating gene expression using microarrays — a technology review, Nat. Cell. , 3, E190, 2001. 28. Schweighoffer, F. , Qualitative gene profiling: a novel tool in genomics and in pharmacogenomics that deciphers messenger RNA isoforms diversity, Pharmacogenomics, 1, 187, 2000.

65, 471, 2001. 25. Ramakrishnan, R. , 30, e30, 2002. 26. Ramdas, L. , 2, research0047, 2001. 27. Schulze, A. , Navigating gene expression using microarrays — a technology review, Nat. Cell. , 3, E190, 2001. 28. Schweighoffer, F. , Qualitative gene profiling: a novel tool in genomics and in pharmacogenomics that deciphers messenger RNA isoforms diversity, Pharmacogenomics, 1, 187, 2000. 29. L. , Functional genomics: technological challenges and opportunities, Physiol. Genomics, 1, 25, 1999. 30.

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An introduction to toxicogenomics by Michael E. Burczynski


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