Animal Models in Toxicology by Shayne C. Gad PDF

By Shayne C. Gad

ISBN-10: 0824754077

ISBN-13: 9780824754075

Even though i've got but to learn the ebook in its entirety, i've got skimmed via a number of chapters & i locate that a lot of the innovations seem to be written in redundancy. maybe i've got excessive expectancies, yet might be concepts which are played within the comparable demeanour among species may be consolidated and referenced. the data for real toxicology within the a number of species is especially helpful.

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Example text

Ziegler, D. M. (1988). Flavin-containing monooxygenase: Catalytic mechanism and specificities. Drug Metab. Rev. 19, 1–32. fm Page 19 Thursday, August 31, 2006 10:30 PM CHAPTER 2 The Mouse Toxicology: Shayne C. Gad Gad Consulting Services Pathology: Charles H. Frith Toxicology Pathology Associates Dawn G. Goodman PATHCO, Inc. Byron G. Boysen Hazleton Wisconsin, Inc. Metabolism: Shayne C. 130 TOXICOLOGY History The domesticated mouse of North America and Europe (Mus musculus) is the most widely used animal in medical research.

31, 382–389. Gonzales, F. (1988). The molecular biology of cytochrome P-450s. Pharmacol. Rev. 40, 243–288. , and Schmelas, A. (1985). Age-development and inducibility of hepatic glutathione Stransfersase activities in mice, rats, rabbits and guinea-pigs. Comp. Biochem. Physiol. 80C, 85–90. , and Klaassen, C. (1983). Hepatic phase I and phase II biotransformations in quail and trout: Comparison to other species commonly used in toxicity testing. Toxicol. Appl. Pharmacol. 67, 430–441. Guengerich, F.

Toxicol. 18, 81–96. Levy, R. , Thummel, K. , Tragen, W. , Hanslen, P. , and Eichelbaum, M. (2000). Metabolic drug interactions. Philadelphia: Lippincott, Williams & Wilkins. Lewis, D. F. V. (2001). Guide to cytochrome P450. Philadelphia: Taylor & Francis. , and Bryan, G. (1973). Enzymatic N-acetylation of carcinogenic aromatic amines by liver cytosol of species displaying different oran susceptibilities. Biochem. Pharmacol. 22, 1581–1588. , and Gram, T. (1975). Comparison of in vitro drug metabolism by lung, liver, and kidney of several common laboratory species.

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Animal Models in Toxicology by Shayne C. Gad

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